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The Population Biology of Tuberculosis$
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Christopher Dye

Print publication date: 2015

Print ISBN-13: 9780691154626

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691154626.001.0001

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Risk and Variation

Risk and Variation

Chapter:
(p.64) Chapter 3 Risk and Variation
Source:
The Population Biology of Tuberculosis
Author(s):

Christopher Dye

Publisher:
Princeton University Press
DOI:10.23943/princeton/9780691154626.003.0003

This chapter examines the factors that affect the risk of exposure to Mycobacterium tuberculosis infection and the risk of developing tuberculosis. Exposure to infection depends on a wide range of exogenous factors linked to the environment, the pathogen and the structure of the human host population. The purpose of identifying such risk factors is to help explain the distribution and abundance of infection and disease in populations, as well as find ways of mitigating the risks to individuals and populations as a means of TB control. This chapter takes a dynamic view of the causes of TB, where risk factors determine the rates of transition between states of health. It discusses comparative risk assessment, dynamic risk assessment, the use of epidemiological models to help refine questions about risk and etiology, and variation in risk of developing TB with age and sex.

Keywords:   exposure risk, Mycobacterium tuberculosis, TB infection, tuberculosis, risk factors, TB control, comparative risk assessment, dynamic risk assessment, epidemiological models, etiology

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