This chapter is an overview of the scope and originality of Eli Stein's contributions to analysis. His work deals with representation theory, classical Fourier analysis, and partial differential equations. He was the first to appreciate the interplay among these subjects, and to perceive the fundamental insights in each field arising from that interplay. No one else really understands all three fields, hence the need for this chapter. However, deep understanding of three fields of mathematics is by no means sufficient to lead to Stein's main ideas. Rather, at crucial points, Stein has shown extraordinary originality, without which no amount of work or knowledge could have succeeded.