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NeuroThe New Brain Sciences and the Management of the Mind$
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Nikolas Rose and Joelle M. Abi-Rached

Print publication date: 2013

Print ISBN-13: 9780691149608

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691149608.001.0001

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PRINTED FROM PRINCETON SCHOLARSHIP ONLINE (www.princeton.universitypressscholarship.com). (c) Copyright Princeton University Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in PRSO for personal use.date: 01 July 2022

What’s Wrong with Their Mice?

What’s Wrong with Their Mice?

(p.82) Chapter Three What’s Wrong with Their Mice?

Nikolas Rose

Joelle M. Abi-Rached

Princeton University Press

This chapter discusses the use of animals to explore issues relating to human cognition, emotion, volition, and their pathologies. Researchers who use animal models in their work point to similarities in the genomes of the two species, in the structure of mouse and human brain, in patterns of brain activation, in neural mechanisms at the cellular and molecular level, in responses to drugs and so forth, perhaps with reference to evolution and the principle of conservation across species when it comes to the most basic aspects of living organisms, including their brains. The chapter then examines four interconnected themes: the question of the artificiality of the laboratory situation within which animal experiments are conducted; the idea of a model in behavioral and psychiatric research; the specificity of the human and the elision of history and human sociality; and the problem of translation.

Keywords:   human cognition, animal models, mouse brain, human brain, brain activation, neural mechanisms, artificiality, animal experiments, behavioral research, psychiatric research

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