This introductory chapter discusses the generation and transformation of expert knowledge and practices in connection with the phenomenon of Alzheimer disease (AD) in an era of increasing uncertainties and recognition of apparently boundless complexity. Emphasis is given to the way in which debates in the Alzheimer world are played out in research and clinical settings, in medical and media publications, at major conferences, and in talks for public consumption, and with what potential effects on the millions of healthy people who will be systematically monitored if and when an era of prevention becomes routinized. Also included are excerpts from extensive interviews with individuals who have undergone testing in research settings, including genetic testing.
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