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The Alzheimer ConundrumEntanglements of Dementia and Aging$
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Margaret Lock

Print publication date: 2013

Print ISBN-13: 9780691149783

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691149783.001.0001

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Making and Remaking Alzheimer Disease

Making and Remaking Alzheimer Disease

(p.26) Chapter 1 Making and Remaking Alzheimer Disease
The Alzheimer Conundrum

Margaret Lock

Princeton University Press

This chapter focuses on the “discovery” of Alzheimer disease (AD) and a somewhat condensed genealogy of its history to the present time. Emphasis is given to the virtual disappearance of AD for over four decades after its initial identification, followed by its rediscovery in the late 1960s in association with government and medical recognition of aging populations and their impending burden on society. The chapter also discusses the consolidation of what has been the dominant research paradigm in AD research for the past four decades-the amyloid cascade hypothesis, grounded in localization theory. Throughout the study, difficulties in attempting to unravel the entanglement of “normal” aging from dementia, evident from Alois Alzheimer's time, are pointed out.

Keywords:   Alzheimer disease, aging populations, research, amyloid cascade hypothesis, localization theory, dementia, Alois Alzheimer

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