Jump to ContentJump to Main Navigation
The Alzheimer ConundrumEntanglements of Dementia and Aging$
Users without a subscription are not able to see the full content.

Margaret Lock

Print publication date: 2013

Print ISBN-13: 9780691149783

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691149783.001.0001

Show Summary Details
Page of

PRINTED FROM PRINCETON SCHOLARSHIP ONLINE (www.princeton.universitypressscholarship.com). (c) Copyright Princeton University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in PRSO for personal use.date: 24 February 2020

Striving to Standardize Alzheimer Disease

Striving to Standardize Alzheimer Disease

Chapter:
(p.51) Chapter 2 Striving to Standardize Alzheimer Disease
Source:
The Alzheimer Conundrum
Author(s):

Margaret Lock

Publisher:
Princeton University Press
DOI:10.23943/princeton/9780691149783.003.0003

This chapter considers repeated attempts at diagnostic refinement and standardization of Alzheimer disease (AD). It explores the difficulties of reconciling repeated mismatches between a clinical and a neuropathological diagnosis of AD, as are the discrepancies in diagnoses between specialized memory clinics and general and family practice settings. A diagnosis of AD involves the demonstration at autopsy of neuritic amyloid plaques, neurofibrillary tangles, and also cell loss or shrinkage of brain tissue. For two decades the preeminent model to account for plaque buildup has been the “amyloid cascade hypothesis” that, it is argued, initiates the eventual formation of tangles and other neuropathological changes. The model is currently being questioned by an increasing number of key researchers and continues to be a driving force, even as the entire Alzheimer enterprise moves to include prevention as a major goal.

Keywords:   Alzheimer disease, diagnosis, memory clinics, family practice settings, neuritic amyloid plaques, neurofibrillary tangles, amyloid cascade hypothesis, Alzheimer enterprise

Princeton Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us.