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The Alzheimer ConundrumEntanglements of Dementia and Aging$
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Margaret Lock

Print publication date: 2013

Print ISBN-13: 9780691149783

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691149783.001.0001

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Alzheimer Genes: Biomarkers of Prediction and Prevention

Alzheimer Genes: Biomarkers of Prediction and Prevention

(p.132) Chapter 5 Alzheimer Genes: Biomarkers of Prediction and Prevention
The Alzheimer Conundrum

Margaret Lock

Princeton University Press

This chapter introduces Alzheimer genetics, including an account of the genes associated with rare, familial, early-onset Alzheimer disease (AD). Discussion is included about why such patients are thought of as excellent research subjects in the search for a “cure” not only for early-onset AD but also for the much more common form of late-onset Alzheimer's. The chapter examines the recruitment of a group of Colombian research subjects who come from families with early-onset AD. It then turns to the susceptibility gene, APOE, the ε‎4 variation of which is associated with increased risk for late-onset AD. Epidemiological research makes it clear that the way in which the APOE genotype functions is elusive because its effects are modified by the presence of other genes and by environmental variables.

Keywords:   Alzheimer genetics, Alzheimer disease, genes, APOE, late-onset, early-onset, epidemiological research, environmental variables

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