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The Alzheimer ConundrumEntanglements of Dementia and Aging$
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Margaret Lock

Print publication date: 2013

Print ISBN-13: 9780691149783

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691149783.001.0001

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Chance Untamed and the Return of Fate

Chance Untamed and the Return of Fate

(p.207) Chapter 8 Chance Untamed and the Return of Fate
The Alzheimer Conundrum

Margaret Lock

Princeton University Press

This chapter demonstrates a reader-friendly discussion about the shift in orientation by molecular biologists away from genes per se, into the wider fields of genomics and epigenetics—that is, to the contextualization of genes. Emphasis is given by many of these researchers to the dynamic interaction of DNA with both micro-environments internal to the body and macro-environments external to the body, and their interrelationship. This approach takes into account individual developmental and life course experiences that may bring about long-lasting modification to or even permanent changes in gene function. These emerging epigenetic models embrace complexity and acknowledge irresolvable uncertainty. The effects of historical, political, and social environments on individual biology and lived experience are also recognized, but thus far only spottily researched.

Keywords:   molecular biologists, genomics, epigenetics, DNA, gene function

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