Jump to ContentJump to Main Navigation
The Population Biology of Tuberculosis$
Users without a subscription are not able to see the full content.

Christopher Dye

Print publication date: 2015

Print ISBN-13: 9780691154626

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691154626.001.0001

Show Summary Details
Page of

PRINTED FROM PRINCETON SCHOLARSHIP ONLINE (www.princeton.universitypressscholarship.com). (c) Copyright Princeton University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in PRSO for personal use.date: 23 September 2021

Strains and Drug Resistance

Strains and Drug Resistance

(p.138) Chapter 5 Strains and Drug Resistance
The Population Biology of Tuberculosis

Christopher Dye

Princeton University Press

This chapter examines the geographical distribution of resistant forms of Mycobacterium tuberculosis and their time trends. Apart from drug resistance, there are plenty of other main questions about M. tuberculosis population genetics. To combat epidemics of drug-resistant TB, it is vital to understand why some resistant strains have greater reproductive fitness than drug-susceptible strains. The chapter first provides an overview of genetic variation in M. tuberculosis before discussing resistance (new and acquired) to first-and second-line drugs. It then considers the link between drug resistance and HIV coinfection, global distribution of drug-resistant TB, relative reproductive fitness, and absolute reproductive fitness. It shows that drug resistance is preventable and reversible, but this must be corroborated and expanded with longer series of data from a wider range of countries, countries with high rates of HIV infection (for example, Botswana and South Africa), and those reporting cases of extensively drug-resistant TB (XDR-TB).

Keywords:   geographical distribution, Mycobacterium tuberculosis, drug resistance, population genetics, resistant strains, reproductive fitness, genetic variation, HIV coinfection, absolute reproductive fitness, tuberculosis

Princeton Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us.