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The Population Biology of Tuberculosis$
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Christopher Dye

Print publication date: 2015

Print ISBN-13: 9780691154626

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691154626.001.0001

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(p.162) Chapter 6 TB and HIV/AIDS
The Population Biology of Tuberculosis

Christopher Dye

Princeton University Press

This chapter examines the dual epidemic of tuberculosis and HIV/AIDS. There have been some major successes in the control of both HIV/AIDS and TB. The discovery and widespread use of antiretroviral therapy (ART) is among the greatest advances in public health during the past thirty years. The rise of TB cases in Africa and elsewhere and on the discovery and implementation of control measures raise a series of questions about the population biology of TB linked to HIV/AIDS. The chapter first provides an overview of HIV infection as a risk factor for TB before discussing the global epidemiology of TB linked to HIV/AIDS. It then describes the anatomy of a TB-HIV epidemic, along with TB control in the presence of HIV. In particular, it considers ART and isoniazid preventive therapy. The chapter concludes with the argument that the DOTS strategy is necessary but not sufficient for TB–HIV control.

Keywords:   tuberculosis, HIV/AIDS, antiretroviral therapy, Africa, population biology, HIV infection, epidemiology, TB control, isoniazid preventive therapy, DOTS strategy

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