The basic reproduction number
The basic reproduction number
The basic reproduction number (or ratio) R₀ is arguably the most important quantity in infectious disease epidemiology. It is among the quantities most urgently estimated for infectious diseases in outbreak situations, and its value provides insight when designing control interventions for established infections. From a theoretical point of view R₀ plays a vital role in the analysis of, and consequent insight from, infectious disease models. There is hardly a paper on dynamic epidemiological models in the literature where R₀ does not play a role. R₀ is defined as the average number of new cases of an infection caused by one typical infected individual, in a population consisting of susceptibles only. This chapter shows how R₀ can be characterized mathematically and provides detailed examples of its calculation in terms of parameters of epidemiological models, culminating in a set of algorithms (or “recipes”) for the calculation for compartmental epidemic systems.
Keywords: structured population models, reproduction number, epidemiological models, compartmental epidemic systems, infectious disease epidemiology, infectious diseases, outbreak situations
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