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Viruses as Complex Adaptive Systems$
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Richard Sole and Santiago F. Elena

Print publication date: 2018

Print ISBN-13: 9780691158846

Published to Princeton Scholarship Online: May 2019

DOI: 10.23943/princeton/9780691158846.001.0001

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Virus Dynamics and Arms Races

Virus Dynamics and Arms Races

(p.91) 4 Virus Dynamics and Arms Races
Viruses as Complex Adaptive Systems

Ricard Solé

Santiago F. Elena

Princeton University Press

The life histories of viruses cannot be understood outside the context of their host partners. Because they cannot exist without the environment defined by their target organisms, understanding the behavior of viruses inevitably leads to consideration of how they and their hosts coevolve. Mathematics is also key to understanding evolution. This chapter studies several models describing key aspects of virus–host dynamics on different scales. As an illustrative example, the discussion focuses on the interaction between HIV-1 and the immune system, using both ecological and evolutionary models. The chapter covers HIV multiscale dynamics, population dynamics of HIV, infection, spatial dynamics of HIV-1, antigenic diversity thresholds and AIDS, and viral symbiosis.

Keywords:   virus–host interactions, HIV infection, population dynamics, spatial dynamics, antigenic dynamics, AIDS, viral symbiosis

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