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Biomolecular Feedback Systems$
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Domitilla Del Vecchio and Richard M. Murray

Print publication date: 2014

Print ISBN-13: 9780691161532

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691161532.001.0001

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Biological Circuit Components

Biological Circuit Components

(p.169) Chapter 5 Biological Circuit Components
Biomolecular Feedback Systems

Richard M. Murray

Princeton University Press

This chapter describes some simple circuit components that have been constructed in E. coli cells using the technology of synthetic biology and then considers a more complicated circuit that already appears in natural systems to implement adaptation. It first analyzes the negatively autoregulated gene fabricated in E. coli bacteria, before turning to the toggle switch, which is composed of two genes that mutually repress each other. The chapter next illustrates a dynamical model of a “repressilator”—an oscillatory genetic circuit consisting of three repressors arranged in a ring fashion. The activator–repressor clock is then considered, alongside an incoherent feedforward loop (IFFL). Finally, the chapter examines bacterial chemotaxis, which E. coli use to move in the direction of increasing nutrients.

Keywords:   gene circuits, signal transduction circuits, E. coli, negative autoregulation, toggle switch, repressilator, activator–repressor clock, incoherent feedforward loop, IFFL, bacterial chemotaxis

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