Jump to ContentJump to Main Navigation
Biomolecular Feedback Systems$
Users without a subscription are not able to see the full content.

Domitilla Del Vecchio and Richard M. Murray

Print publication date: 2014

Print ISBN-13: 9780691161532

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691161532.001.0001

Show Summary Details
Page of

PRINTED FROM PRINCETON SCHOLARSHIP ONLINE (www.princeton.universitypressscholarship.com). (c) Copyright Princeton University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in PRSO for personal use.date: 25 May 2020

Biological Circuit Components

Biological Circuit Components

Chapter:
(p.169) Chapter 5 Biological Circuit Components
Source:
Biomolecular Feedback Systems
Author(s):

Richard M. Murray

Publisher:
Princeton University Press
DOI:10.23943/princeton/9780691161532.003.0005

This chapter describes some simple circuit components that have been constructed in E. coli cells using the technology of synthetic biology and then considers a more complicated circuit that already appears in natural systems to implement adaptation. It first analyzes the negatively autoregulated gene fabricated in E. coli bacteria, before turning to the toggle switch, which is composed of two genes that mutually repress each other. The chapter next illustrates a dynamical model of a “repressilator”—an oscillatory genetic circuit consisting of three repressors arranged in a ring fashion. The activator–repressor clock is then considered, alongside an incoherent feedforward loop (IFFL). Finally, the chapter examines bacterial chemotaxis, which E. coli use to move in the direction of increasing nutrients.

Keywords:   gene circuits, signal transduction circuits, E. coli, negative autoregulation, toggle switch, repressilator, activator–repressor clock, incoherent feedforward loop, IFFL, bacterial chemotaxis

Princeton Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us.