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Biomolecular Feedback Systems$
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Domitilla Del Vecchio and Richard M. Murray

Print publication date: 2014

Print ISBN-13: 9780691161532

Published to Princeton Scholarship Online: October 2017

DOI: 10.23943/princeton/9780691161532.001.0001

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PRINTED FROM PRINCETON SCHOLARSHIP ONLINE (www.princeton.universitypressscholarship.com). (c) Copyright Princeton University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in PRSO for personal use.date: 17 April 2021

Design Tradeoffs

Design Tradeoffs

Chapter:
(p.243) Chapter 7 Design Tradeoffs
Source:
Biomolecular Feedback Systems
Author(s):

Richard M. Murray

Publisher:
Princeton University Press
DOI:10.23943/princeton/9780691161532.003.0007

This chapter describes some of the design tradeoffs arising from the interaction between synthetic circuits and the host organism. It first considers the effects of competition for shared cellular resources on circuits' behavior. In particular, circuits (endogenous and exogenous) share a number of cellular resources. The insertion or induction of synthetic circuits in the cellular environment changes for these resources, with possibly undesired repercussions on the functioning of the circuits. Independent circuits may become coupled when they share common resources that are not in overabundance. This fact leads to constraints among the concentrations of proteins in synthetic circuits, which should be accounted for in the design phase. Next, the chapter looks at the effect of biological noise on the design of devices requiring high gains. Specifically, the chapter illustrates possible design tradeoffs between retroactivity attenuation and noise amplification that emerge due to the intrinsic noise of biomolecular reactions.

Keywords:   design tradeoffs, synthetic circuits, host organism, circuit behavior, independent circuits, cellular resources, biological noise, retroactivity attenuation, noise amplification, biomolecular reactions

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